Publications

 

Oliveira MM, Lourenco MV, Longo F, Kasica NP, Yang W, Ureta G, Ferreira DDP, Mendonca PHJ, Bernales S, Ma T, De Felice FG, Klann E, Ferreira ST. Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity and memory in mouse models of Alzheimer’s disease. Science Signaling. 2021 Feb 02. doi: 10.1126/scisignal.abc5429.

Lourenco MV, Ribeiro FC, Sudo FK, Drummond C, Assunção N, Vanderborght B, Tovar-Moll F, Mattos P, De Felice FG, Ferreira ST. Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2020 Jun 21. doi: 10.1002/dad2.12034.

de Freitas GBLourenco MV, De Felice FG. Protective actions of exercise-related FNDC5/irisin in memory and Alzheimer's disease. Journal of Neurochemistry. 2020 May 12. doi: 10.1111/jnc.15039.

 

Fontana IC, Zimmer AR, Rocha AS, Gosmann G, Souza DO, Lourenco MV, Ferreira ST, Zimmer ER. Amyloid-β oligomers in cellular models of Alzheimer's disease. Journal of Neurochemistry. 2020 Apr 22. doi: 10.1111/jnc.15030.

Altimus CM, Marlin BJ, Charalambakis NE, Colón-Rodriquez A, Glover EJ, Izbicki P, Johnson A, Lourenco MV, Makinson RA, McQuail J, Obeso I, Padilla-Coreano N, Wells MF; for Training Advisory Committee. The next 50 years of neuroscience. Journal of Neuroscience. 2020 Jan 02. doi: 10.1523/JNEUROSCI.0744-19.2019.

 

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models. Nature Medicine. 2019 Jan 7. 25(1):165-175. doi: 10.1038/s41591-018-0275-4.

Clarke JR, Ribeiro FC, Frozza RL, De Felice FG, Lourenco MVMetabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches. Journal of Alzheimer's Disease. 2018 Mar 16. doi: 10.3233/JAD-179911.

Frozza RL, Lourenco MV, De Felice FG. Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Frontiers in Neuroscience. 2018 Feb 6;12:37. doi: 10.3389/fnins.2018.00037
 

Schaefer N*, Rotermund C*, Blumrich EM*, Lourenco MV*, Joshi P*, Hegemann RU*, Jamwal S, Ali N, García Romero EM, Sharma S, Ghosh S, Sinha JK, Loke H, Jain V, Lepeta K, Salamian A, Sharma M, Golpich M, Nawrotek K, Paidi RK, Shahidzadeh SM, Piermartiri T, Amini E, Pastor V, Wilson Y, Adeniyi PA, Datusalia AK, Vafadari B, Saini V, Suárez-Pozos E, Kushwah N, Fontanet P, Turner AJ. The malleable brain: plasticity of neural circuits and behavior - a review from students to students. Journal of Neurochemistry. 2017 Jun 20. doi: 10.1111/jnc.14107.
 

Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG. Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons. Journal of Biological Chemistry. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525.
 

Brito-Moreira J*, Lourenco MV*, Oliveira MM*, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST. Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice. Journal of Biological Chemistry. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. 
 

Lepeta K*, Lourenco MV*, Schweitzer BC*, Martino Adami PV, Banerjee P, Catuara-Solarz S, de La Fuente Revenga M, Guillem AM, Haidar M, Ijomone OM, Nadorp B, Qi L, Perera ND, Refsgaard LK, Reid KM, Sabbar M, Sahoo A, Schaefer N, Sheean RK, Suska A, Verma R, Vicidomini C, Wright D, Zhang XD, Seidenbecher C. Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students. Journal of Neurochemistry. 2016 Sep;138(6):785-805. doi: 10.1111/jnc.13713.

Oliveira MM, Lourenco MVIntegrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer's Disease. Journal of Neuroscience. 2016 Jan 27;36(4):1053-5. doi: 10.1523/JNEUROSCI.4110-15.2016. 

Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG. Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease. Frontiers in Cellular Neuroscience. 2015 May 26;9:191. doi: 10.3389/fncel.2015.00191. 

De Felice FG, Lourenco MV. Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease. Frontiers in Aging Neuroscience. 2015 May 19;7:94. doi: 10.3389/fnagi.2015.00094. 

Madeira C*, Lourenco MV*, Vargas-Lopes C, Suemoto CK, Brandão CO, Reis T, Leite RE, Laks J, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Ferreira ST, Panizzutti R. d-serine levels in Alzheimer's disease: implications for novel biomarker development. Translational Psychiatry. 2015 May 5;5:e561. doi: 10.1038/tp.2015.52.

Lourenco MV, Ferreira ST, De Felice FG. Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes. Progress in Neurobiology. 2015 Jun;129:37-57. doi: 10.1016/j.pneurobio.2015.03.003.

De Felice FG, Lourenco MV, Ferreira ST. How does brain insulin resistance develop in Alzheimer's disease? Alzheimer's & Dementia. 2014 Feb;10(1 Suppl):S26-32. doi: 10.1016/j.jalz.2013.12.004.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metabolism. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

Freitas-Correa L, Lourenco MV, Acquarone M, da Costa RF, Galina A, Rehen SK, Ferreira ST. 2,4-Dinitrophenol induces neural differentiation of murine embryonic stem cells. Stem Cell Research. 2013 Nov;11(3):1407-16. doi: 10.1016/j.scr.2013.09.016.

Lourenco MV, Ledo JH. Targeting Alzheimer's pathology through PPARγ signaling: modulation of microglial function. Journal of Neuroscience. 2013 Mar 20;33(12):5083-4. doi: 10.1523/JNEUROSCI.0172-13.2013.