1. Molecular mechanisms of memory failure in Alzheimer's disease
Memory impairment is one of the earliest and main symptoms of Alzheimer's disease (AD). We are interested in understanding the molecular changes that take place in the brain to trigger memory failure in AD. By using cell and molecular biology, pharmacology and behavioral approaches, we aim to identify critical molecules that act to promote neuronal and synapse failure. Our results have identified mechanisms linked to impaired hormonal signaling, proteostasis and neurotransmission. We continue to pursue those
2. Translational research in Alzheimer's disease: biomarkers and drug targets
AD is still in search of effective diagnostics and therapeutics. We perform translational research spanning from primary cell culture to patient samples to identify potential biomarkers and effective targets for AD prevention, detection and treatment.
3. Molecular mechanisms of cognition and mood
Memory and mood are complex traits that involve several brain regions and intricate molecular mechanisms to properly develop. Using mice as our experimental model, we are interested in dissecting molecular mechanisms that contribute to the physiology of memory and mood.